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Treatment of gonorrhea with single-dose thiamphenicol in Kenya.

Abstract
The efficacy of a single 2.5-g dose of thiamphenicol against infection with penicillinase-producing strains of Neisseria gonorrhoeae (PPNG) or non-penicillinase-producing strains (non-PPNG) was studied in a two-phase clinical trial in Nairobi. The first phase included men who had had a urethral discharge for less than seven days, were infected with either PPNG or non-PPNG, and had not received previous treatment. The second phase included men with PPNG infections that had not responded to treatment with penicillin. The overall cure rate (determined by follow-up examinations and cultures three and ten days after treatment) was 90.6% in the first phase of the study and 92.1% in the second phase. A second 2.5-g dose of thiamphenicol was administered to four of the six patients in the second phase whose cultures yielded gonococci after the initial dose; the infections of all four patients were cured. The results of disk diffusion tests of gonococcal isolates did not correlate well with the outcome of treatment.
AuthorsH Nsanze, L J D'Costa, D M Owili, F Ilako, Ndinya-Achola, P Piot
JournalSexually transmitted diseases (Sex Transm Dis) 1984 Oct-Dec Vol. 11 Issue 4 Suppl Pg. 376-8 ISSN: 0148-5717 [Print] UNITED STATES
PMID6441281 (Publication Type: Journal Article)
Chemical References
  • Penicillinase
  • beta-Lactamases
  • Thiamphenicol
Topics
  • Adult
  • Drug Evaluation
  • Gonorrhea (drug therapy)
  • Humans
  • Male
  • Microbial Sensitivity Tests
  • Neisseria gonorrhoeae (drug effects, enzymology)
  • Penicillinase (biosynthesis)
  • Thiamphenicol (administration & dosage, therapeutic use)
  • beta-Lactamases (biosynthesis)

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