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Amifloxacin activity against well-defined gentamicin-resistant, gram-negative bacteria.

Abstract
Amifloxacin (WIN 49375) activity against a well-defined group of gentamicin-resistant gram-negative bacilli was compared with the activity of 11 other antimicrobial agents. For all strains, amifloxacin and norfloxacin were the most active agents, followed by cefotaxime and moxalactam. For Acinetobacter sp. only amifloxacin had an achievable MIC for 90% of the strains. Amifloxacin joins other newly developed DNA gyrase inhibitors as potentially useful agents for infections due to aminoglycoside-resistant gram-negative bacilli.
AuthorsJ F John Jr, J A Twitty
JournalAntimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 26 Issue 5 Pg. 781-4 (Nov 1984) ISSN: 0066-4804 [Print] United States
PMID6440481 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
Chemical References
  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Fluoroquinolones
  • Gentamicins
  • Quinolines
  • Ciprofloxacin
  • amifloxacin
Topics
  • Anti-Bacterial Agents (pharmacology)
  • Anti-Infective Agents
  • Ciprofloxacin (analogs & derivatives)
  • Enterobacter (drug effects)
  • Escherichia coli (drug effects)
  • Fluoroquinolones
  • Gentamicins (pharmacology)
  • Gram-Negative Bacteria (drug effects)
  • Klebsiella pneumoniae (drug effects)
  • Microbial Sensitivity Tests
  • Pseudomonas aeruginosa (drug effects)
  • Quinolines (pharmacology)

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