IgG heavy-chain (Gm) allotypes and HLA-antigens in insulin-dependent diabetes mellitus in Korea.

Abstract

Eighty-eight patients with insulin-dependent diabetes mellitus (IDDM) and seventy-two unrelated normal controls in Korea were studied for Gm allotypes and HLA-antigens. Ten Gm phenotypes were found among the Korean population. The phenotype frequencies of Gm axg (1,2,21), Gm ag (1,21), Gm agb0b3b5st (1,21, 11,13,10,15,16) and Gm agfb0b1b3b4b5 (1,21,3,11,5,13,14,10) were higher than the other Gm allotypes, but there was no significant difference between patients and controls. HLA-BW54 was found in 15% of patients who had any of those Gm allotypes (Gm axg, Gm agb0b3b5st, Gm ab0b3b5st). However there was no significant difference in frequency as compared with controls.

• Authors: K Okimoto, Y Nakao, H Matsumoto, H K Min, E J Kim, T H Lee, J S Yoon, S Higa, T Oura, G Mimura
• Journal: The Tohoku journal of experimental medicine (Tohoku J Exp Med) Vol. 141 Suppl Pg. 283-7 (Dec 1983) ISSN: 0040-8727 [Print] Japan
• PMID: 6440310 (Publication Type: Journal Article)

Chemical References

• HLA Antigens
• Immunoglobulin Allotypes
• Immunoglobulin G
• Immunoglobulin Heavy Chains

Topics

• Diabetes Mellitus, Type 1 (genetics, immunology)
• HLA Antigens (genetics, immunology)
• Humans
• Immunoglobulin Allotypes (genetics, immunology)
• Immunoglobulin G (genetics, immunology)
• Immunoglobulin Heavy Chains (genetics, immunology)
• Korea
• Phenotype