The role of
alumina cream (AC) epileptic
granulomas in producing clinical convulsions and EEG spikes was evaluated by excising and transplanting such
granulomas from donors to recipient cats. In donors,
granulomas were produced by single microinjections of AC into the right motor cortex and were subsequently excised during latent premature (P), mature (M), convulsive, and remission stages. The excised
granulomas from donors were homogenized and injected into the homologous cortices of the recipient cats. The epileptogenic effect of the AC
granuloma transplant in the recipients and the antiepileptogenic effect of the AC
granuloma excision in the donors were evaluated by the presence or absence of clinical convulsions and the maximal EEG spike density at the right motor cortex (MSD) after lesion excision and transplant. In addition, a correlation between MSD (spikes/10 min) of donors and recipients and the
aluminum content (microgram/ml) in
granuloma and perilesional cortex of control epileptic cats (neither excised nor transplanted) was established during latent P, M, convulsive, and remission stages. The epileptogenic effect of AC
granulomas transplanted into recipients was significantly larger when they were excised from donors in latent P and M than in convulsive, and in convulsive than in remission. The antiepileptogenic effect of AC
granuloma excision in donors was significantly larger in latent P than in latent M and convulsive, and in convulsive than in remission. The
aluminum content of AC
granuloma and perilesional and contralateral cortices in controls was significantly larger in latent P and M than in convulsive and in convulsive than in remission.(ABSTRACT TRUNCATED AT 250 WORDS)