[Influence of family history, irradiation and anti-cancer drug (mitomycin C) on the occurrence of multiple primary neoplasms in breast carcinoma patients].

Abstract

The influence of family history, irradiation and anti-cancer drug (Mitomycin C) on the occurrence of multiple primary neoplasms was analysed using the person-year method in 1359 Japanese breast carcinoma patients. There were 111 multiple primary neoplasms, including bilateral breast cancer, in 109 patients; the incidence rate was 0.0072 per person-year. The incidence rate in patients with a family history of cancer was 1.29 times higher than in those without. In the bilateral breast cancer group there was about a 3 times higher frequency of family history of breast cancer. Irradiation therapy raised the occurrence of multiple primary neoplasms 1.28 fold, and Mitomycin C (40 mg) had no effect on the occurrence of neoplasms during a 10-year observation period.

• Authors: M Yoshimoto, G Sakamoto, H Sugano, F Kasumi, A Fukami, K Kuno
• Journal: Gan no rinsho. Japan journal of cancer clinics (Gan No Rinsho) Vol. 30 Issue 11 Pg. 1361-8 (Sep 1984) ISSN: 0021-4949 [Print] Japan
• PMID: 6438367 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibiotics, Antineoplastic
• Mitomycins
• Cobalt
• Mitomycin

Topics

• Adult
• Aged
• Antibiotics, Antineoplastic (therapeutic use)
• Breast Neoplasms (drug therapy, epidemiology, genetics, radiotherapy)
• Cobalt (therapeutic use)
• Female
• Humans
• Japan
• Middle Aged
• Mitomycin
• Mitomycins (therapeutic use)
• Neoplasms, Multiple Primary (epidemiology)
• Statistics as Topic