HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Pathology of chronic polychlorinated biphenyl (PCB) feeding in rats.

Abstract
The hepatocarcinogenic effect of Clophen A 30 and Clophen A 60 was tested in male weanling rats by long-term feeding over a period of 832 days. The mortality rate was investigated in 100-day intervals. In the first 800 days liver carcinoma accounted for 21% of necropsies in the Clophen A 60 group but only 2% of the necropsies in the Clophen A 30 group and none in the control animals. The tumors were first observed after 700 days. After 800 days hepatocellular carcinoma was the most common lesion observed in the Clophen A 60 animals (61%) whereas it was only observed in 3% of animals in the Clophen A 30 group and 2% in the controls. Preneoplastic lesions, such as foci of hepatocellular alterations and neoplastic nodules, were first observed after Day 500. The incidence of foci predominated in all time intervals, but an increase in neoplastic nodules and hepatocellular carcinomas was observed with increased time. There was a marked trend from foci to neoplastic nodule to hepatocellular carcinoma with time. The total mortality rate and the incidence of thymoma, inflammatory lesions of the urogenital tract, in the experiment were significantly reduced by Clophen administration. Whether this protective effect could be induced by polychlorinated biphenyls (PCBs) is discussed.
AuthorsE Schaeffer, H Greim, W Goessner
JournalToxicology and applied pharmacology (Toxicol Appl Pharmacol) Vol. 75 Issue 2 Pg. 278-88 (Sep 15 1984) ISSN: 0041-008X [Print] United States
PMID6433511 (Publication Type: Journal Article)
Chemical References
  • clophen A60
  • clophen A30
  • Polychlorinated Biphenyls
Topics
  • Administration, Oral
  • Animals
  • Female
  • Liver Neoplasms (chemically induced, mortality, pathology)
  • Male
  • Neoplasms, Experimental (mortality, pathology)
  • Polychlorinated Biphenyls (toxicity)
  • Rats
  • Rats, Inbred Strains
  • Thymoma (chemically induced)
  • Thymus Neoplasms (chemically induced)
  • Urogenital Neoplasms (chemically induced)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: