Differential effect of fluorinated analogs of TRH on the cardiovascular system and prolactin release.

Abstract

The effects of thyrotropin-releasing hormone (TRH) and the TRH-analogs, 4-fluoro-Im-TRH (4-F-TRH) and 2-trifluoromethyl-Im-TRH (2-TFM-TRH), on the cardiovascular system and prolactin (PRL) release were examined in conscious rats. TRH (2.8 or 28 nmol) injected into the anterior hypothalamus produced dose-dependent increments in blood pressure and heart rate; plasma PRL was increased twofold after the higher dose of TRH. 4-F-TRH had effects similar to those of TRH on both the cardiovascular and PRL response. In contrast, the 2-TFM-TRH was significantly less active than TRH or 4-F-TRH in eliciting tachycardia, yet was noticeably more potent in affecting PRL release. These data suggest that the receptors for TRH-induced PRL release may be different from TRH-receptors which mediate central cardiovascular responses.

• Authors: G Feuerstein, D Lozovsky, L A Cohen, V M Labroo, K L Kirk, I J Kopin, A I Faden
• Journal: Neuropeptides (Neuropeptides) Vol. 4 Issue 4 Pg. 303-10 (Jun 1984) ISSN: 0143-4179 [Print] Netherlands
• PMID: 6433221 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• thyrotropin-releasing hormone, 4-fluoroimidazole-
• Thyrotropin-Releasing Hormone
• Prolactin
• thyrotropin-releasing hormone, 2-fluoromethylimidazole-

Topics

• Animals
• Blood Pressure (drug effects)
• Heart Rate (drug effects)
• Hypothalamus, Anterior (drug effects)
• Male
• Prolactin (blood)
• Rats
• Rats, Inbred Strains
• Thyrotropin-Releasing Hormone (analogs & derivatives, pharmacology)