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A new antitumor antibiotic, kazusamycin.

Abstract
A new antibiotic kazusamycin, was isolated from the culture broth of Streptomyces sp. No. 81-484, which shows antitumor activity against experimental murine tumors. This antibiotic did not possess antibacterial activity against Gram-positive and Gram-negative bacteria, but showed strong cytotoxic activity against HeLa cells in vitro. The chemical and physico-chemical properties of kazusamycin suggest that the molecular formula of this antibiotic is C33H48O7 (MW 556).
AuthorsI Umezawa, K Komiyama, H Oka, K Okada, S Tomisaka, T Miyano, S Takano
JournalThe Journal of antibiotics (J Antibiot (Tokyo)) Vol. 37 Issue 7 Pg. 706-11 (Jul 1984) ISSN: 0021-8820 [Print] England
PMID6432763 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antibiotics, Antineoplastic
  • Fatty Acids, Unsaturated
  • kazusamycin A
Topics
  • Animals
  • Antibiotics, Antineoplastic (isolation & purification, pharmacology, therapeutic use)
  • Fatty Acids, Unsaturated
  • Fermentation
  • HeLa Cells (drug effects)
  • Leukemia P388 (drug therapy)
  • Magnetic Resonance Spectroscopy
  • Mice
  • Microbial Sensitivity Tests
  • Sarcoma 180 (drug therapy)
  • Streptomyces (analysis)

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