Abstract |
A new antibiotic kazusamycin, was isolated from the culture broth of Streptomyces sp. No. 81-484, which shows antitumor activity against experimental murine tumors. This antibiotic did not possess antibacterial activity against Gram-positive and Gram-negative bacteria, but showed strong cytotoxic activity against HeLa cells in vitro. The chemical and physico-chemical properties of kazusamycin suggest that the molecular formula of this antibiotic is C33H48O7 (MW 556).
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Authors | I Umezawa, K Komiyama, H Oka, K Okada, S Tomisaka, T Miyano, S Takano |
Journal | The Journal of antibiotics
(J Antibiot (Tokyo))
Vol. 37
Issue 7
Pg. 706-11
(Jul 1984)
ISSN: 0021-8820 [Print] England |
PMID | 6432763
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibiotics, Antineoplastic
- Fatty Acids, Unsaturated
- kazusamycin A
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Topics |
- Animals
- Antibiotics, Antineoplastic
(isolation & purification, pharmacology, therapeutic use)
- Fatty Acids, Unsaturated
- Fermentation
- HeLa Cells
(drug effects)
- Leukemia P388
(drug therapy)
- Magnetic Resonance Spectroscopy
- Mice
- Microbial Sensitivity Tests
- Sarcoma 180
(drug therapy)
- Streptomyces
(analysis)
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