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Effects of thyrotropin-releasing hormone (TRH) and a TRH analogue, MK-771, on punished responding of squirrel monkeys.

Abstract
The effects of thyrotropin-releasing hormone (TRH) and an enzyme-resistant analogue, MK-771, were compared on punished responding of squirrel monkeys maintained either by food presentation or stimulus-shock termination. Both TRH and MK-771 (1.0-30 mg/kg IM) produced dose-related decreases in punished responding maintained by food presentation and dose-related increases in punished responding maintained by shock termination. TRH was more potent than MK-771 in altering punished response rates maintained by either event.
AuthorsL S Brady, J O Valentine, J E Barrett
JournalPsychopharmacology (Psychopharmacology (Berl)) Vol. 83 Issue 2 Pg. 151-4 ( 1984) ISSN: 0033-3158 [Print] Germany
PMID6431464 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Thiazolidines
  • Thyrotropin-Releasing Hormone
  • pyro(l-alpha-aminoadipyl)-L-histidyl-L-thiazolidine-4-carboxamide
Topics
  • Animals
  • Conditioning, Psychological (drug effects)
  • Food
  • Male
  • Punishment
  • Saimiri
  • Thiazolidines
  • Thyrotropin-Releasing Hormone (analogs & derivatives, pharmacology)

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