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Effective treatment of Wilson's disease with oral zinc sulphate: two case reports.

Abstract
Most patients with Wilson's disease are treated with the potentially toxic cupriuretic agent penicillamine. The toxicity of zinc taken by mouth is low, and long term administration induces a negative copper balance. Two patients with severe neurological symptoms were given zinc sulphate by mouth three times daily in doses of 200 mg, later increased to 300 mg. One patient, a 21 year old man, started to receive zinc sulphate after his condition had deteriorated during treatment with cupriuretic drugs. The other, a 27 year old woman, was treated from the start with zinc sulphate. The conditions of both patients improved appreciably, and they were still receiving treatment with zinc sulphate roughly two years later. Effective depletion of body copper stores was shown by an intravenous radiocopper loading test and liver biopsy. No side effects were found. Wilson's disease may effectively be treated with zinc sulphate alone.
AuthorsT U Hoogenraad, C J Van den Hamer, J Van Hattum
JournalBritish medical journal (Clinical research ed.) (Br Med J (Clin Res Ed)) Vol. 289 Issue 6440 Pg. 273-6 (Aug 04 1984) ISSN: 0267-0623 [Print] England
PMID6430436 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Sulfates
  • Zinc Sulfate
  • Copper
  • Zinc
Topics
  • Administration, Oral
  • Adult
  • Copper (metabolism)
  • Female
  • Hepatolenticular Degeneration (drug therapy, metabolism)
  • Humans
  • Liver (metabolism)
  • Male
  • Sulfates (administration & dosage, therapeutic use)
  • Zinc (administration & dosage, therapeutic use)
  • Zinc Sulfate

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