[Cooperative phase II study of releasing tegafur (SF-SP) against advanced digestive cancers].

A Phase II Study of single oral administration of SF-SP containing sustained-release granules of tegafur was conducted in 37 cases of advanced cancers by 9 institutions in the Hokkaido area. Two capsules each containing 200 or 250 mg of SF-SP were orally administered twice daily for a total of either 800 or 1000 mg per day. The results were as follows: Of the 24 evaluable cases PR was observed in 4 cases. (16.7%) The observed efficacy rate by cancer type was 23.5% for gastric cancer and toxicity was observed in 10 (27.8%) of 35 subject cases. These results thus indicate SF-SP to be therapeutically effective for treatment of gastric cancers, with mild toxicity.
AuthorsJ Ibayashi
JournalGan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 11 Issue 7 Pg. 1414-9 (Jul 1984) ISSN: 0385-0684 [Print] JAPAN
PMID6430244 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Delayed-Action Preparations
  • Tegafur
  • Fluorouracil
  • Administration, Oral
  • Adult
  • Aged
  • Colonic Neoplasms (drug therapy)
  • Delayed-Action Preparations
  • Digestive System Neoplasms (drug therapy)
  • Drug Evaluation
  • Esophageal Neoplasms (drug therapy)
  • Female
  • Fluorouracil (analogs & derivatives)
  • Humans
  • Male
  • Middle Aged
  • Pancreatic Neoplasms (drug therapy)
  • Stomach Neoplasms (drug therapy)
  • Tegafur (administration & dosage, therapeutic use)

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