Transfer of intestine-derived diamines into tumour cells during treatment of Ehrlich-ascites--carcinoma-bearing mice with polyamine anti-metabolites.

Abstract

Treatment of Ehrlich-ascites-carcinoma-bearing mice with methylglyoxal bis(guanylhydrazone) alone or in combination with 2-difluoromethylornithine greatly enhanced the transfer of intragastrically administered radioactive putrescine and cadaverine into the carcinoma cells. Difluoromethylornithine alone did not have any effect on the accumulation of intestine-derived diamines in the tumour cells. The frequently reported restoration of difluoromethylornithine-induced polyamine depletion on administration of methylglyoxal bis(guanylhydrazone) is in all likelihood attributable to a profound inhibition of intestinal diamine oxidase (EC 1.4.3.6), resulting in an enhanced entry of intestinal (bacterial) diamines into general circulation and finally into tumour cells.

• Authors: A Kallio, P Nikula, J Jänne
• Journal: The Biochemical journal (Biochem J) Vol. 218 Issue 2 Pg. 641-4 (Mar 01 1984) ISSN: 0264-6021 [Print] England
• PMID: 6424664 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Diamines
• Guanidines
• Ornithine
• Cadaverine
• Mitoguazone
• Putrescine
• Eflornithine

Topics

• Animals
• Cadaverine (metabolism)
• Carcinoma, Ehrlich Tumor (metabolism)
• Diamines (metabolism)
• Eflornithine
• Guanidines (pharmacology)
• Mice
• Mitoguazone (pharmacology)
• Ornithine (analogs & derivatives, pharmacology)
• Putrescine (metabolism)