Synthetic hpGRF 1-40 stimulates growth hormone and inhibits prolactin secretion in normal children and children with isolated growth hormone deficiency.

Abstract

Intravenously administered synthetic hpGRF 1-40 at doses of 0.1, 0.33 and 1.0 microgram/kg increased plasma GH in a dose-dependent fashion in 4 normal prepubertal children. hpGRF 1-40 at the dose of 1.0 microgram/kg stimulated GH release, though to a lesser extent than in normals, in 7 children with isolated GH-deficiency (IGHD) but failed to do so in a patient with craniopharyngioma. In all normal children and 6/7 patients with IGHD, hpGRF 1-40 at all doses used induced a clear and sustained lowering of plasma prolactin levels; this effect was lacking in the patient with craniopharyngioma. hpGRF 1-40 had no effect on plasma FSH, LH, TSH or glucose levels nor did it influence pulse rate, blood pressure, or body temperature. These results indicate that hpGRF 1-40 is a potent stimulus to GH release in normal prepubertal children and holds promise for treatment of GH-deficient children. In addition, in both normal children and children with IGHD, hpGRF 1-40 is a potent suppressor of prolactin levels.

• Authors: C Pintor, V Fanni, S Loche, V Locatelli, S G Cella, F Villa, F Minuto, R Corda, E E Müller
• Journal: Peptides (Peptides) 1983 Nov-Dec Vol. 4 Issue 6 Pg. 929-33 ISSN: 0196-9781 [Print] United States
• PMID: 6424103 (Publication Type: Journal Article)

Chemical References

• Peptide Fragments
• somatotropin releasing factor 40
• Prolactin
• Growth Hormone
• Growth Hormone-Releasing Hormone

Topics

• Adolescent
• Child
• Female
• Growth Hormone (blood, deficiency, metabolism)
• Growth Hormone-Releasing Hormone
• Humans
• Kinetics
• Male
• Peptide Fragments
• Prolactin (blood, metabolism)
• Reference Values