Unnecessary polypharmacy in patients with frequent seizures.

35 patients with a mean seizure frequency of 15 attacks per months were studied. 19 were taking a 2-drug combination, 13 a 3-drug combination and 3 patients a 4-drug combination. Treatment was reduced to monotherapy in 21 patients and to a 2-drug combination in 8 patients. There was an increase in seizure frequency in 6 patients taking a 2-drug combination when an attempt was made to reduce the treatment to monotherapy. Reduction in polypharmacy resulted in an improvement in seizure control in 54% of patients. Carbamazepine replaced polypharmacy as monotherapy in 19 patients and phenytoin and sodium valproate in 2 other patients. Improvement in seizure control was associated with optimal blood levels in 17 patients taking carbamazepine and in the 2 patients taking sodium valproate and phenytoin. Serum levels in all patients taking 2-drug combination were within the optimal range.
AuthorsN Callaghan, R O'Dwyer, J Keating
JournalActa neurologica Scandinavica (Acta Neurol Scand) Vol. 69 Issue 1 Pg. 15-9 (Jan 1984) ISSN: 0001-6314 [Print] DENMARK
PMID6422691 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anticonvulsants
  • Primidone
  • Carbamazepine
  • Clonazepam
  • Ethosuximide
  • Valproic Acid
  • Phenytoin
  • Phenobarbital
  • Adolescent
  • Adult
  • Anticonvulsants (administration & dosage)
  • Carbamazepine (administration & dosage)
  • Child
  • Clonazepam (administration & dosage)
  • Drug Therapy, Combination
  • Epilepsy (drug therapy)
  • Ethosuximide (administration & dosage)
  • Female
  • Humans
  • Male
  • Phenobarbital (administration & dosage)
  • Phenytoin (administration & dosage)
  • Primidone (administration & dosage)
  • Valproic Acid (administration & dosage)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: