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Unnecessary polypharmacy in patients with frequent seizures.

Abstract
35 patients with a mean seizure frequency of 15 attacks per months were studied. 19 were taking a 2-drug combination, 13 a 3-drug combination and 3 patients a 4-drug combination. Treatment was reduced to monotherapy in 21 patients and to a 2-drug combination in 8 patients. There was an increase in seizure frequency in 6 patients taking a 2-drug combination when an attempt was made to reduce the treatment to monotherapy. Reduction in polypharmacy resulted in an improvement in seizure control in 54% of patients. Carbamazepine replaced polypharmacy as monotherapy in 19 patients and phenytoin and sodium valproate in 2 other patients. Improvement in seizure control was associated with optimal blood levels in 17 patients taking carbamazepine and in the 2 patients taking sodium valproate and phenytoin. Serum levels in all patients taking 2-drug combination were within the optimal range.
AuthorsN Callaghan, R O'Dwyer, J Keating
JournalActa neurologica Scandinavica (Acta Neurol Scand) Vol. 69 Issue 1 Pg. 15-9 (Jan 1984) ISSN: 0001-6314 [Print] DENMARK
PMID6422691 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anticonvulsants
  • Primidone
  • Carbamazepine
  • Clonazepam
  • Ethosuximide
  • Valproic Acid
  • Phenytoin
  • Phenobarbital
Topics
  • Adolescent
  • Adult
  • Anticonvulsants (administration & dosage)
  • Carbamazepine (administration & dosage)
  • Child
  • Clonazepam (administration & dosage)
  • Drug Therapy, Combination
  • Epilepsy (drug therapy)
  • Ethosuximide (administration & dosage)
  • Female
  • Humans
  • Male
  • Phenobarbital (administration & dosage)
  • Phenytoin (administration & dosage)
  • Primidone (administration & dosage)
  • Valproic Acid (administration & dosage)

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