Potent antitumor promoting activity of N-6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, in mouse skin tumor formation induced by 7,12-dimethylbenz[a]anthracene plus teleocidin.

Abstract	A calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) markedly inhibited the promoting activity of teleocidin on formation of skin tumors in mice initiated by 7,12-dimethylbenz[a]anthracene. This result strongly indicates that the critical action of the Ca2+-calmodulin system is responsible for tumor promotion in mouse skin.
Authors	H Nishino, A Iwashima, T Nakadate, R Kato, H Fujiki, T Sugimura
Journal	Carcinogenesis (Carcinogenesis) Vol. 5 Issue 2 Pg. 283-5 (Feb 1984) ISSN: 0143-3334 [Print] England
PMID	6421505 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Alkaloids Benz(a)Anthracenes Carcinogens Lyngbya Toxins Phospholipids Sulfonamides Trifluoperazine teleocidins 9,10-Dimethyl-1,2-benzanthracene W 7
Topics	9,10-Dimethyl-1,2-benzanthracene (toxicity) Alkaloids (toxicity) Animals Benz(a)Anthracenes (toxicity) Carcinogens (toxicity) Drug Antagonism Female Fibroblasts (drug effects, metabolism) Lyngbya Toxins Mice Mice, Inbred ICR Phospholipids (biosynthesis) Skin Neoplasms (chemically induced) Sulfonamides (pharmacology) Trifluoperazine (pharmacology)

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