HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Effects of KCl and insulin on benzimidazole-inhibited canine gastric secretion.

Abstract
The final step in acid secretion is believed to result from the H+-K+-ATPase-mediated exchange of H+ in the parietal cell, with K+ in the lumen. To study the K+ secretion we used Picoprazole and insulin separately and together to inhibit gastric secretion stimulated in gastric fistula dogs with histamine (100 micrograms X kg-1 X h-1). Picoprazole, a substituted benzimidazole (750 mg/kg), reduced gastric H+ concentration and volume with a rise in K+ concentration [( K+]) to 20-25 meq/l. Insulin alone inhibited acid output to the same extent as Picoprazole but with a marked fall in [K+]. Insulin (0.6 U/kg) given with Picoprazole did not alter inhibition of H+ but prevented the large decrease in gastric juice [K+]. An injection of KCl (1 meq/kg) 1 h after Picoprazole did not alter the effects of the inhibitor. Pepsin secretion after insulin was delayed by Picoprazole, whereas during bethanechol chloride infusion (80 micrograms X kg-1 X h-1) pepsin output was reduced for a shorter period and to a lesser extent than acid. We concluded that insulin affects gastric H+ and K+ secretion by a mechanism not related to H+-K+-ATPase and that Picoprazole affects pepsin secretion probably indirectly via its effect on the parietal cell, where its action is quite consistent with an effect limited to inhibition of the H+-K+-ATPase of the parietal cell.
AuthorsB I Hirschowitz, J Fong
JournalThe American journal of physiology (Am J Physiol) Vol. 245 Issue 6 Pg. G739-44 (Dec 1983) ISSN: 0002-9513 [Print] United States
PMID6419624 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Benzimidazoles
  • Chlorides
  • Insulin
  • Potassium Chloride
  • Histamine
  • Sodium
  • benzimidazole
  • Pepsin A
  • Potassium
Topics
  • Animals
  • Benzimidazoles (pharmacology)
  • Chlorides (analysis)
  • Dogs
  • Gastric Juice (drug effects, metabolism)
  • Histamine (pharmacology)
  • Hydrogen-Ion Concentration
  • Insulin (pharmacology)
  • Kinetics
  • Pepsin A (metabolism)
  • Potassium (analysis)
  • Potassium Chloride (pharmacology)
  • Sodium (analysis)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: