Abstract |
Abdominal vagotomy on Day 8 of pregnancy in rats decreased the number of live fetuses at Day 16 and increased the number of resorbing fetuses. The activity of delta5-3beta-hydroxysteroid dehydrogenase (3beta-HSD) in the corpus luteum and interstitial gland, LH and progesterone values in plasma and progesterone values in ovarian tissue were all lower in vagotomized rats than in sham-operated controls. Ovarian PGF levels were not affected. We suggest that these effects were caused by a direct effect of vagotomy on LH secretion which in turn lowers 3beta-HSD activity and progesterone levels in ovarian tissue and plasma, leading to fetal resorption.
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Authors | I E Lawrence Jr, H W Burden, T M Louis |
Journal | Journal of reproduction and fertility
(J Reprod Fertil)
Vol. 53
Issue 1
Pg. 131-6
(May 1978)
ISSN: 0022-4251 [Print] England |
PMID | 641892
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Prostaglandins F
- Progesterone
- Luteinizing Hormone
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Topics |
- Animals
- Female
- Fetal Death
- Fetal Resorption
- Histocytochemistry
- Luteinizing Hormone
(blood)
- Ovary
(innervation, metabolism)
- Pregnancy
- Progesterone
(metabolism)
- Prostaglandins F
(metabolism)
- Rats
- Vagotomy
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