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Effect of abdominal vagotomy of the pregnant rat on LH and progesterone concentrations and fetal resorption.

Abstract
Abdominal vagotomy on Day 8 of pregnancy in rats decreased the number of live fetuses at Day 16 and increased the number of resorbing fetuses. The activity of delta5-3beta-hydroxysteroid dehydrogenase (3beta-HSD) in the corpus luteum and interstitial gland, LH and progesterone values in plasma and progesterone values in ovarian tissue were all lower in vagotomized rats than in sham-operated controls. Ovarian PGF levels were not affected. We suggest that these effects were caused by a direct effect of vagotomy on LH secretion which in turn lowers 3beta-HSD activity and progesterone levels in ovarian tissue and plasma, leading to fetal resorption.
AuthorsI E Lawrence Jr, H W Burden, T M Louis
JournalJournal of reproduction and fertility (J Reprod Fertil) Vol. 53 Issue 1 Pg. 131-6 (May 1978) ISSN: 0022-4251 [Print] England
PMID641892 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Prostaglandins F
  • Progesterone
  • Luteinizing Hormone
Topics
  • Animals
  • Female
  • Fetal Death
  • Fetal Resorption
  • Histocytochemistry
  • Luteinizing Hormone (blood)
  • Ovary (innervation, metabolism)
  • Pregnancy
  • Progesterone (metabolism)
  • Prostaglandins F (metabolism)
  • Rats
  • Vagotomy

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