Effect of CO2-induced hyperventilation on carbon tetrachloride (CCl4) levels following acute CCl4 poisoning.

To study under standardized experimental conditions the effect of a CO2-induced hyperventilation therapy on carbon tetrachloride (CCl4) levels following acute CCl4 poisoning, rats received 2.5 ml CCl4/kg BW by gastric intubation and were subsequently either treated by CO2-induced hyperventilation or kept in an atmosphere containing air. Peak levels of CCl4 were observed in the fat, liver and blood 3-6 h after the intoxication and were found to be considerably lower in animals treated by CO2-induced hyperventilation compared to their respective controls. These data therefore strongly support the efficacy of the CO2-induced hyperventilation therapy for CCl4 intoxication.
AuthorsJ Gellert, L Goldermann, R Teschke
JournalIntensive care medicine (Intensive Care Med) Vol. 9 Issue 6 Pg. 333-7 ( 1983) ISSN: 0342-4642 [Print] UNITED STATES
PMID6418782 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Carbon Dioxide
  • Carbon Tetrachloride
  • Adipose Tissue (metabolism)
  • Animals
  • Carbon Dioxide (administration & dosage)
  • Carbon Tetrachloride (blood, metabolism)
  • Carbon Tetrachloride Poisoning (metabolism)
  • Female
  • Hyperventilation (chemically induced)
  • Liver (metabolism)
  • Rats
  • Rats, Inbred Strains
  • Time Factors

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