Abstract |
To study under standardized experimental conditions the effect of a CO2-induced hyperventilation therapy on carbon tetrachloride (CCl4) levels following acute CCl4 poisoning, rats received 2.5 ml CCl4/kg BW by gastric intubation and were subsequently either treated by CO2-induced hyperventilation or kept in an atmosphere containing air. Peak levels of CCl4 were observed in the fat, liver and blood 3-6 h after the intoxication and were found to be considerably lower in animals treated by CO2-induced hyperventilation compared to their respective controls. These data therefore strongly support the efficacy of the CO2-induced hyperventilation therapy for CCl4 intoxication.
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Authors | J Gellert, L Goldermann, R Teschke |
Journal | Intensive care medicine
(Intensive Care Med)
Vol. 9
Issue 6
Pg. 333-7
( 1983)
ISSN: 0342-4642 [Print] United States |
PMID | 6418782
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Carbon Dioxide
- Carbon Tetrachloride
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Topics |
- Adipose Tissue
(metabolism)
- Animals
- Carbon Dioxide
(administration & dosage)
- Carbon Tetrachloride
(blood, metabolism)
- Carbon Tetrachloride Poisoning
(metabolism)
- Female
- Hyperventilation
(chemically induced)
- Liver
(metabolism)
- Rats
- Rats, Inbred Strains
- Time Factors
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