Different effectiveness of tocainide and hydrochlorothiazide in paramyotonia congenita with hyperkalemic episodic paralysis.

Abstract

We investigated the effectiveness of tocainide and hydrochlorothiazide on muscular symptoms in a patient with paramyotonia congenita and episodic attacks of hyperkalemic paralysis. Generalized weakness was evoked by exercise and potassium loading. Myotonia and weakness were evoked by local muscle cooling. Tocainide prevented myotonia and weakness induced by cooling, but failed to prevent hyperkalemic weakness. Hydrochlorothiazide prevented hyperkalemic weakness, but did not influence symptoms evoked by cooling. These results suggest that, in this disorder, two different mechanisms cause muscular weakness.

• Authors: K Ricker, R Böhlen, R Rohkamm
• Journal: Neurology (Neurology) Vol. 33 Issue 12 Pg. 1615-8 (Dec 1983) ISSN: 0028-3878 [Print] United States
• PMID: 6417558 (Publication Type: Case Reports, Journal Article)

Chemical References

• Hydrochlorothiazide
• Tocainide
• Lidocaine
• Potassium

Topics

• Adult
• Humans
• Hydrochlorothiazide (therapeutic use)
• Hyperkalemia (complications, drug therapy)
• Hypothermia, Induced
• Lidocaine (analogs & derivatives, therapeutic use)
• Male
• Myotonia Congenita (drug therapy, etiology)
• Paralysis (complications, drug therapy)
• Physical Exertion
• Potassium
• Tocainide