Reduced sensitivity to beta-lactam antibiotics arising during ceftazidime treatment of Pseudomonas aeruginosa infections.

Abstract

Pseudomonas aeruginosa isolated from two patients with empyema and one with bronchopneumonia became less sensitive after treatment with ceftazidime, while Ps. aeruginosa persisted in a patient with an infected compound fracture of the tibia treated with ceftazidime but did not become less sensitive. The reduction in sensitivity to ceftazidime, which was small, was accompanied by resistance to azlocillin but there are little reduction in sensitivity to carbenicillin. The resistant strains produced increased amounts of the chromosomally-mediated cephalosporinase produced by most isolates of Ps. aeruginosa. Variants with reduced sensitivity to ceftazidime, which resembled those that developed in vivo, were selected in vitro from each of the initial ceftazidime-sensitive isolates.

• Authors: A King, K Shannon, S Eykyn, I Phillips
• Journal: The Journal of antimicrobial chemotherapy (J Antimicrob Chemother) Vol. 12 Issue 4 Pg. 363-70 (Oct 1983) ISSN: 0305-7453 [Print] England
• PMID: 6417101 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Bacterial Agents
• Cephalosporins
• Ceftazidime
• beta-Lactamases

Topics

• Adult
• Anti-Bacterial Agents (pharmacology)
• Ceftazidime
• Cephalosporins (therapeutic use)
• Drug Resistance, Microbial
• Humans
• Male
• Middle Aged
• Pseudomonas Infections (drug therapy)
• Pseudomonas aeruginosa (drug effects, enzymology)
• beta-Lactamases (analysis)