Immunoactive peptides, FK-156 and FK-565. II. Restoration of host resistance to microbial infection in immunosuppressed mice.

The immunoactive peptides, FK-156 and its analogue, FK-565 were evaluated in various models of mice immunosuppressed with cyclophosphamide, hydrocortisone, mitomycin C, carrageenan and tumor cells. Treatment with FK-156 (subcutaneous) and FK-565 (oral) markedly restored host defense ability against microbial infection. The therapeutic effect of ticarcillin or gentamicin alone against pseudomonal infection in cyclophosphamide- and hydrocortisone-treated mice and tumor-bearing mice was much lower than in normal mice. The therapeutic effect of these antibiotics against pseudomonal infection in immunosuppressed mice was enhanced markedly by combined use with FK-156. The killing ability of macrophages and polymorphonuclear leukocytes of the immunosuppressed mice was also markedly enhanced by dosing with FK-156.
AuthorsY Yokota, Y Mine, Y Wakai, Y Watanabe, M Nishida, S Goto, S Kuwahara
JournalThe Journal of antibiotics (J Antibiot (Tokyo)) Vol. 36 Issue 8 Pg. 1051-8 (Aug 1983) ISSN: 0021-8820 [Print] JAPAN
PMID6415030 (Publication Type: Journal Article)
Chemical References
  • Adjuvants, Immunologic
  • Amino Acids, Diamino
  • Antibiotics, Antineoplastic
  • Mitomycins
  • Oligopeptides
  • Mitomycin
  • Diaminopimelic Acid
  • FK 156
  • FK 565
  • Cyclophosphamide
  • Carrageenan
  • Hydrocortisone
  • Adjuvants, Immunologic (therapeutic use)
  • Amino Acids, Diamino (therapeutic use)
  • Animals
  • Antibiotics, Antineoplastic (pharmacology)
  • Bacterial Infections (immunology)
  • Carrageenan (pharmacology)
  • Cyclophosphamide (pharmacology)
  • Diaminopimelic Acid (analogs & derivatives, therapeutic use)
  • Drug Synergism
  • Hydrocortisone (pharmacology)
  • Immunity, Innate
  • Immunosuppression
  • Male
  • Mice
  • Mice, Inbred ICR
  • Mitomycin
  • Mitomycins (pharmacology)
  • Oligopeptides
  • Phagocytosis (drug effects)
  • Sarcoma 180 (immunology)

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