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Effect of metiamide, a histamine H2-receptor antagonist on reserpine-induced gastric ulcers and acid secretion.

Abstract
The effect of metiamide on reserpine-induced gastric ulcers and on gastric secretion during 6 h after ip administration was investigated in conscious intact rats and in rats with chronic gastric fistula. Reserpine, 3 mg/kg ip increased substantially the concentration of gastric acid in the first 4 h. Metiamide given every 3 h in a low dose (0.01 mumol/kg) intensified reserpine-induced gastric ulcers and also significantly increased the reserpine-induced acid concentration and output. In larger doses, (50-100 mumol/kg) metiamide considerably diminished gastric ulcer development and decreased gastric acid concentration. Given every 2 h metiamide in doses of 50-100 mumol/kg almost completely abolished gastric ulcer formation and markedly reduced the secretion of gastric acid in reserpinized rats. Anti-ulcer effect of metiamide was stronger than its antisecretory action, suggesting also the antiulcer action of metiamide other than inhibition of acid secretion. The results suggest that in conscious rats histamine H2-receptors are involved in reserpine-induced gastric ulcer development and gastric acid secretion. The antiulcer effect of metiamide may in part depend on its antisecretory action.
AuthorsJ Hano, J Bugajski, C Wantuch
JournalPolish journal of pharmacology and pharmacy (Pol J Pharmacol Pharm) Vol. 35 Issue 1 Pg. 15-27 ( 1983) ISSN: 0301-0244 [Print] Poland
PMID6412220 (Publication Type: Journal Article)
Chemical References
  • Receptors, Histamine
  • Receptors, Histamine H2
  • Metiamide
  • Reserpine
  • Pepsin A
  • Thiourea
Topics
  • Animals
  • Gastric Acid (metabolism)
  • Male
  • Metiamide (pharmacology)
  • Pepsin A (metabolism)
  • Rats
  • Rats, Inbred Strains
  • Receptors, Histamine (physiology)
  • Receptors, Histamine H2 (physiology)
  • Reserpine (pharmacology)
  • Stomach Ulcer (chemically induced, drug therapy, physiopathology)
  • Thiourea (analogs & derivatives)
  • Time Factors

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