Abstract |
The covalent binding of hexamethylmelamine (HMM) and its metabolites was studied in liver, tumor, blood, kidney, spleen, lung, brain, heart, and small intestine after a single IP injection of 2,4,6-14C-hexamethylmelamine (50 mg/kg) to C57Bl/6J female mice bearing 20-day-old M5076/73A ovarian cancer. Covalent binding to tissue macromolecules was measured 2, 10, and 40 h after injection of the drug. At 2 h liver and small intestine showed the highest levels of irreversibly bound metabolites, the lowest being found in brain and heart. Except in the small intestine, where a decrease was observed between 2 and 10 h, the level of covalent binding was constant up to 40 h. HMM metabolism was also studied. Tissue distribution of pentamethylmelamine (PMM), 2,2,4,6-tetramethylmelamine (TMM), and 2,4,6-trimethylmelamine (TriMM) was determined at the three times considered. At 2 h the drug was already extensively metabolized, TriMM being the major metabolite among those determined.
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Authors | E Garattini, T Colombo, M G Donelli, P Catalani, M Bianchi, M D'Incalci, C Pantarotto |
Journal | Cancer chemotherapy and pharmacology
(Cancer Chemother Pharmacol)
Vol. 11
Issue 1
Pg. 51-5
( 1983)
ISSN: 0344-5704 [Print] Germany |
PMID | 6411375
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Antineoplastic Agents
- Triazines
- N(2),N(2),N(4),N(6)-tetramethylmelamine
- 2,4,6-trimethylmelamine
- Altretamine
- pentamethylmelamine
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Topics |
- Altretamine
(analogs & derivatives, metabolism)
- Animals
- Antineoplastic Agents
(metabolism)
- Female
- Mice
- Mice, Inbred C57BL
- Ovarian Neoplasms
(metabolism)
- Tissue Distribution
- Triazines
(metabolism)
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