Assay of HBV DNA in the plasma of HBV-carrier chimpanzees superinfected with non-A, non-B hepatitis.

Abstract

A dot hybridisation technique was used to monitor the levels of hepatitis B virus (HBV) DNA in the plasma of two HBV-carrier chimpanzees which had been inocula ed with documented infectious non-A, non-B hepatitis agents. A marked decrease in the quantity of HBV DNA in the plasma during the acute phase of the non-A, non-B hepatitis was observed in both carriers. The possible role of interferon or a similar antiviral agent in modulation of the HBV-carrier state is discussed. Hybridisation may become, in due course, the method of choice for examining blood samples for infectious hepatitis B virus.

• Authors: T J Harrison, K N Tsiquaye, A J Zuckerman
• Journal: Journal of virological methods (J Virol Methods) Vol. 6 Issue 5 Pg. 295-302 (May 1983) ISSN: 0166-0934 [Print] Netherlands
• PMID: 6409916 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• DNA, Viral
• Hepatitis B Surface Antigens
• DNA-Directed DNA Polymerase

Topics

• Animals
• Carrier State (microbiology)
• DNA, Viral (blood)
• DNA-Directed DNA Polymerase (blood)
• Hepatitis B (complications, microbiology)
• Hepatitis B Surface Antigens (analysis)
• Hepatitis B virus (analysis)
• Hepatitis C (complications, microbiology)
• Hepatitis, Viral, Human (microbiology)
• Nucleic Acid Hybridization
• Pan troglodytes