Continuous therapy with sulfamethoxazole-trimethoprim in patients with chronic granulomatous disease.

Abstract

In a retrospective study, the effect of long-term treatment with sulfamethoxazole-trimethoprim was evaluated in nine male patients with chronic granulomatous disease. During this treatment, a marked reduction was observed in the number of infectious episodes, the number of causative agents, and the number of surgical interventions. Furthermore, a significant reduction in days of hospitalization per year was found. The mean observation period was six years before and four years during treatment. Transient alopecia was observed in one patient during therapy. We conclude that prophylactic treatment with sulfamethoxazole-trimethoprim is beneficial in patients with chronic granulomatous disease.

• Authors: R S Weening, P Kabel, P Pijman, D Roos
• Journal: The Journal of pediatrics (J Pediatr) Vol. 103 Issue 1 Pg. 127-30 (Jul 1983) ISSN: 0022-3476 [Print] United States
• PMID: 6408232 (Publication Type: Journal Article)

Chemical References

• Trimethoprim
• Sulfamethoxazole

Topics

• Adolescent
• Adult
• Child
• Drug Therapy, Combination
• Granulomatous Disease, Chronic (complications, drug therapy, microbiology, surgery)
• Humans
• Infection Control
• Infections (etiology)
• Length of Stay
• Male
• Retrospective Studies
• Sulfamethoxazole (therapeutic use)
• Trimethoprim (therapeutic use)