Antitumor effect of 5-fluorouracil in combination with some additives which stimulate the formation of antineoplastic 5-fluorouracil nucleotides.

Abstract

Both ribose 1-phosphate and deoxyribose 1-phosphate, which were effective in increasing the formation of antineoplastic fluoronucleotides and fluoro-RNA from 5-fluorouracil (5-FU) in the intact cells of Ehrlich mouse ascites tumor, potentiated the antitumor effect of 5-FU. Ethylenediaminetetraacetate, which stimulates the formation of only fluororibonucleotides from 5-FU in intact Ehrlich tumor cells, was ineffective in the potentiation of 5-FU antitumor activity. The relationship between the increased metabolite formation from 5-FU and the antitumor effect of 5-FU is discussed.

• Authors: O Tamemasa, M Tezuka
• Journal: Gan (Gan) Vol. 74 Issue 2 Pg. 285-90 (Apr 1983) ISSN: 0016-450X [Print] Japan
• PMID: 6407888 (Publication Type: Journal Article)

Chemical References

• Pentosephosphates
• Ribosemonophosphates
• 2-deoxyribose 1-phosphate
• Edetic Acid
• Fluorouracil

Topics

• Animals
• Carcinoma, Ehrlich Tumor (drug therapy)
• Cells, Cultured
• Drug Therapy, Combination
• Edetic Acid (pharmacology)
• Fluorouracil (administration & dosage, metabolism)
• Leukemia L1210 (drug therapy)
• Mice
• Pentosephosphates (administration & dosage)
• Ribosemonophosphates (administration & dosage)