The protective effect of gamma-glutamyl L-dopa on the glycerol treated rat model of acute renal failure.

Abstract

gamma-Glutamyl L-dopa, a renal pro-drug for dopamine, was administered to rats before and after injection of glycerol, and to a control group which received water in place of glycerol. A third group of rats was given glycerol but no gamma-glutamyl L-dopa. The plasma creatinine in rats given gamma-glutamyl L-dopa and glycerol was significantly lower than in rats receiving glycerol alone. The fall in urine creatinine excretion, and polyuria, after glycerol was reduced by gamma-glutamyl L-dopa and the natriuresis abolished. gamma-Glutamyl L-dopa given alone caused a 4000-fold increase in urine dopamine excretion, associated with a natriuresis. The administration of gamma-glutamyl L-dopa reduces the severity of renal failure produced by glycerol.

• Authors: I F Casson, D A Clayden, G F Cope, M R Lee
• Journal: Clinical science (London, England : 1979) (Clin Sci (Lond)) Vol. 65 Issue 2 Pg. 159-64 (Aug 1983) ISSN: 0143-5221 [Print] England
• PMID: 6407799 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• gamma-glutamyl DOPA
• Dihydroxyphenylalanine
• Sodium
• Creatinine
• Glycerol
• Dopamine

Topics

• Acute Kidney Injury (chemically induced, metabolism, prevention & control)
• Animals
• Creatinine (metabolism)
• Dihydroxyphenylalanine (analogs & derivatives, therapeutic use)
• Dopamine (urine)
• Glycerol
• Male
• Rats
• Rats, Inbred Strains
• Sodium (metabolism)