[Analgetic drug intolerance].

Abstract

Reactions as intolerance to aspirin and food additives were diagnosed in 41 cases during November 1979 -- March 1982. Allergy to pyrazolone-drugs were observed in 20 cases during the same period. 24% of the patients with intolerance to aspirin had also an intolerance to tartrazine. There were no familial occurrence of aspirin intolerance. Four patients had mainly asthma, 37 patients urticaria. New aspects of the pathogenesis of aspirin intolerance -- modulation of arachidonate metabolism and complement activation -- are discussed.

• Authors: H Merk, G Goerz
• Journal: Zeitschrift fur Hautkrankheiten (Z Hautkr) Vol. 58 Issue 8 Pg. 535-42 (Apr 15 1983) ISSN: 0301-0481 [Print] Germany
• Vernacular Title: Analgetika-Intoleranz.
• PMID: 6407223 (Publication Type: English Abstract, Journal Article)

Chemical References

• Analgesics
• Arachidonic Acids
• Arachidonic Acid
• Tartrazine
• Aspirin

Topics

• Analgesics (adverse effects)
• Arachidonic Acid
• Arachidonic Acids (metabolism)
• Aspirin (adverse effects)
• Asthma (chemically induced)
• Complement Activation
• Drug Hypersensitivity (etiology)
• Humans
• Tartrazine (adverse effects)
• Urticaria (chemically induced)