Electric shock titration in squirrel monkeys following administration of nantradol, levonantradol, or N-methyl levonantradol.

Abstract

The effects of some cannabinoid-related analgesics were examined in squirrel monkeys responding under a schedule of shock titration. Nantradol (0.1-0.3 mg/kg), levonantradol (0.03-0.1 mg/kg), or N-methyl levonantradol (0.01-0.03 mg/kg) increased the level at which shock was maintained, but did not change rates of responding. Nantradol effects were not blocked by naloxone (0.3-3.0 mg/kg), but they were attenuated following daily administration of nantradol.

• Authors: L A Dykstra
• Journal: Psychopharmacology (Psychopharmacology (Berl)) Vol. 79 Issue 4 Pg. 322-4 ( 1983) ISSN: 0033-3158 [Print] Germany
• PMID: 6407046 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Analgesics
• Phenanthridines
• Naloxone
• N-methylnantradol
• nantradol

Topics

• Analgesics (administration & dosage)
• Animals
• Cebidae (physiology)
• Electroshock
• Male
• Naloxone (pharmacology)
• Phenanthridines (administration & dosage)
• Saimiri (physiology)