[Long-term treatment with a new antihypertensive drug: flutonidin].

Abstract

The aim of this research was to evaluate the effectiveness and the tolerability of flutonidin: a new clonidine-like antihypertensive compound. 30 patients (9 man and 21 women, mean age 60.5), affected by mild-moderate essential hypertension, have been randomized in two homogeneous groups of 15 patients, and treated respectively with flutonidin (F) 2 mg/day and clonidine (C) 0.3 mg/day for a period of 15 days at the Hospital. We obtained 60% normalization of blood pressure values in patients of group F and 66% in the patients of group C. The treatment continued after discharge from Hospital at the same doses for a six months period in the 9 normalized patients of group F and in the 10 normalized patients of group C. The results showed an increase of the blood pressure mean values in both groups. Our data seem to indicate that: 1) Flutonidin and clonidine have comparable antihypertensive effect. 2) A partial loss of activity has been observed for both drugs. This phenomenon has been already noted in long-term treatment with clonidine. 3) The tolerability of two compounds resulted satisfactory.

• Authors: F Nicrosini, C Pasotti
• Journal: Minerva medica (Minerva Med) Vol. 74 Issue 21 Pg. 1297-300 (May 19 1983) ISSN: 0026-4806 [Print] Italy
• Vernacular Title: Trattamento a lungo termine con un nuovo farmaco antiipertensivo: flutonidin.
• PMID: 6406947 (Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Imidazoles
• Clonidine
• flutonidine

Topics

• Adult
• Aged
• Blood Pressure (drug effects)
• Clinical Trials as Topic
• Clonidine (therapeutic use)
• Female
• Heart Rate (drug effects)
• Humans
• Hypertension (drug therapy)
• Imidazoles (therapeutic use)
• Long-Term Care
• Male
• Middle Aged