HLA-B15 association with erythema multiforme.

Abstract

Erythema multiforme (EM) is a cutaneous reaction pattern which follows numerous infections, drugs, neoplastic and inflammatory disorders in some individuals. We undertook a prospective study of thirty-eight HLA specificities of the -A, -B, and -C series in 16 Caucasian patients with EM and in 140 local Caucasian controls. Seven of 16 patients (44%) with EM and 5 of 9 patients (55%) with EM following herpes simplex infections possessed the HLA-B15 antigen, compared to 7% of local controls and 11.6% of the 1980 WHO Workshop Caucasian controls. Both associations were highly significant (p = 0.0125 and p = 0.02) when corrected for 38 HLA antigens. This is the first reported HLA association for erythema multiforme, a disease which may be a host-specific immune response to various antigens, determined in part by genes linked to HLA-B15.

• Authors: M Duvic, E G Reisner, D V Dawson, E Ciftan
• Journal: Journal of the American Academy of Dermatology (J Am Acad Dermatol) Vol. 8 Issue 4 Pg. 493-6 (Apr 1983) ISSN: 0190-9622 [Print] United States
• PMID: 6406563 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• HLA Antigens
• HLA-B Antigens
• HLA-B15 Antigen

Topics

• Erythema Multiforme (genetics, immunology)
• Genes, MHC Class II
• HLA Antigens (immunology)
• HLA-B Antigens
• HLA-B15 Antigen
• Humans