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Tolerance to the anti-pentylenetetrazole effects of diazepam in the mouse.

Abstract
The protective effects of acute and chronic diazepam administration (4 mg/kg) against seizures induced by pentylenetetrazole (PTZ) and picrotoxin were investigated. Considering the incidence of tonic-clonic convulsions, tolerance to the protective effects of diazepam was evident by day 5 if the mice were challenged with PTZ (120 mg/kg), by day 10 if the challenge was picrotoxin (8 mg/kg) and by day 20 if the challenge was PTZ (105 mg/kg). Diazepam retained its protective effects against tonic-clonic convulsions induced by PTZ (90 and 60 mg/kg) for 45 days, but the incidence of myoclonic jerks revealed tolerance after 5 days.
AuthorsS E File
JournalPsychopharmacology (Psychopharmacology (Berl)) Vol. 79 Issue 2-3 Pg. 284-6 ( 1983) ISSN: 0033-3158 [Print] Germany
PMID6405440 (Publication Type: Journal Article)
Chemical References
  • Picrotoxin
  • Diazepam
  • Pentylenetetrazole
Topics
  • Animals
  • Diazepam (pharmacology)
  • Dose-Response Relationship, Drug
  • Drug Tolerance
  • Male
  • Mice
  • Pentylenetetrazole (antagonists & inhibitors)
  • Picrotoxin (pharmacology)
  • Time Factors

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