Long-term tiapamil treatment of patients with angina pectoris.

Abstract

The effects of a 12-week oral treatment with tiapamil (200 mg t.i.d.) were compared to those of placebo treatment in a group of 20 men with coronary heart disease. There was a slight reduction of anginal symptoms (p less than 0.05) and a tendency to less nitroglycerin consumption (p less than 0.07). There were no statistically significant differences between the treatments in blood pressure, exercise tolerance during repeated exercise tests, ECG conduction intervals, or routine laboratory tests. No adverse side-effects were encountered. It seems that tiapamil may be beneficial in preventing angina pectoris, but a higher oral dose must be used.

• Authors: Y Salorinne, J J Himberg, E Eskelinen
• Journal: Clinical cardiology (Clin Cardiol) Vol. 6 Issue 4 Pg. 171-5 (Apr 1983) ISSN: 0160-9289 [Print] United States
• PMID: 6404577 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Calcium Channel Blockers
• Propylamines
• Tiapamil Hydrochloride

Topics

• Aged
• Angina Pectoris (prevention & control)
• Calcium Channel Blockers (administration & dosage, therapeutic use)
• Coronary Disease (drug therapy)
• Electrocardiography
• Exercise Test
• Humans
• Long-Term Care
• Male
• Middle Aged
• Propylamines (administration & dosage, therapeutic use)
• Tiapamil Hydrochloride