HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

ONO-3144, a new anti-inflammatory drug and its possible mechanism of action.

Abstract
Anti-inflammatory activities of ONO-3144 have been studied in various experimental models. This compound showed an inhibitory effect on increased vascular permeability and acute inflammation. In the carrageenin test the activity of ONO-3144 was comparable to that of indomethacin (IM), while in the dextran, albumin, yeast and scald edema test it was more potent than that of IM. Unlike IM, phenylbutazone (PB) and tiaramide (TI), ONO-3144 showed marked inhibitory effects on H2O2-induced hemolysis and lipid peroxidation. In the prostaglandin (PG) biosynthesis series, ONO-3144 did not inhibit cyclooxygenase activity but stimulated PG hydroperoxidase activity, facilitated conversion to PGH2 and also inhibited thromboxane (Tx) synthetase. The findings suggest that ONO-3144 is potentially a new type of anti-inflammatory drug. Possible sites of action of ONO-3144 are discussed.
AuthorsH Aishita, T Morimura, T Obata, Y Miura, T Miyamoto, M Tsuboshima, Y Mizushima
JournalArchives internationales de pharmacodynamie et de therapie (Arch Int Pharmacodyn Ther) Vol. 261 Issue 2 Pg. 316-27 (Feb 1983) ISSN: 0003-9780 [Print] Belgium
PMID6404228 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Anti-Inflammatory Agents
  • Lipid Peroxides
  • Propiophenones
  • 2-aminomethyl-4-tert-butyl-6-propionylphenol
  • Hydrogen Peroxide
  • Prostaglandin-Endoperoxide Synthases
  • Thromboxane-A Synthase
  • Phenylbutazone
  • Indomethacin
Topics
  • Animals
  • Anti-Inflammatory Agents
  • Autolysis (physiopathology)
  • Capillary Permeability (drug effects)
  • Edema (drug therapy)
  • Hydrogen Peroxide (pharmacology)
  • Indomethacin (pharmacology)
  • Lipid Peroxides (metabolism)
  • Male
  • Mice
  • Phenylbutazone (pharmacology)
  • Propiophenones (pharmacology)
  • Prostaglandin-Endoperoxide Synthases (metabolism)
  • Rats
  • Rats, Inbred Strains
  • Thromboxane-A Synthase (metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: