Inhibition of melanogenesis in B16-F1 melanoma cells after exposure to diflubenzuron.

Abstract

The insect growth regulator diflubenzuron was found to be a potent inhibitor of melanosome synthesis and release in mouse melanoma cell cultures, and after three to five successive passages of melanoma cells in growth medium containing this compound, these cells were unable to produce monolayers in untreated medium and were incapable of inducing tumor formation in mice. This is the first time that an insect growth regulator has been shown to have a deleterious effect on malignant cells of animals.

• Authors: J O Norman, S M Meola
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 23 Issue 2 Pg. 313-6 (Feb 1983) ISSN: 0066-4804 [Print] United States
• PMID: 6404219 (Publication Type: Journal Article)

Chemical References

• Juvenile Hormones
• Melanins
• Diflubenzuron

Topics

• Animals
• Cells, Cultured
• Diflubenzuron (pharmacology)
• Juvenile Hormones (pharmacology)
• Melanins (biosynthesis)
• Melanoma (drug therapy, metabolism, ultrastructure)
• Mice