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Corneal epithelial dysplasia after trifluridine use.

Abstract
Prolonged topical trifluridine treatment of herpes simplex keratitis in three elderly patients produced slightly raised dysplastic corneal epithelial lesions. The involved epithelium had a ground-glass appearance and exhibited opaque cells, edema, and spindle-shaped surface cells. Histopathology demonstrated severe cellular atypism, loss of cell polarity, dyskeratosis, parakeratosis, and a few mitotic figures. The pathological change was apparently intraepithelial. After scraping, the edema and opaque cells in the regenerated epithelium gradually disappeared in 3-4 months on cessation of trifluridine therapy. In one patient recurrence of dendritic keratitis, 5 weeks after scraping, was treated by topical bromovinyldeoxyuridine eye drops. Since severe epithelial dysplasia may represent a precancerous condition, prolonged use of trifluridine should be avoided.
AuthorsP C Maudgal, B Van Damme, L Missotten
JournalGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie (Graefes Arch Clin Exp Ophthalmol) Vol. 220 Issue 1 Pg. 6-12 ( 1983) ISSN: 0721-832X [Print] Germany
PMID6403411 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antiviral Agents
  • brivudine
  • Bromodeoxyuridine
  • Trifluridine
  • Thymidine
Topics
  • Age Factors
  • Aged
  • Antiviral Agents (administration & dosage, adverse effects)
  • Bromodeoxyuridine (administration & dosage, analogs & derivatives)
  • Cornea (drug effects, pathology)
  • Corneal Diseases (chemically induced)
  • Epithelium (drug effects, pathology)
  • Humans
  • Keratitis, Dendritic (drug therapy)
  • Male
  • Microscopy, Phase-Contrast
  • Thymidine (analogs & derivatives)
  • Trifluridine (administration & dosage, adverse effects, therapeutic use)

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