Abstract |
Prolonged topical trifluridine treatment of herpes simplex keratitis in three elderly patients produced slightly raised dysplastic corneal epithelial lesions. The involved epithelium had a ground-glass appearance and exhibited opaque cells, edema, and spindle-shaped surface cells. Histopathology demonstrated severe cellular atypism, loss of cell polarity, dyskeratosis, parakeratosis, and a few mitotic figures. The pathological change was apparently intraepithelial. After scraping, the edema and opaque cells in the regenerated epithelium gradually disappeared in 3-4 months on cessation of trifluridine therapy. In one patient recurrence of dendritic keratitis, 5 weeks after scraping, was treated by topical bromovinyldeoxyuridine eye drops. Since severe epithelial dysplasia may represent a precancerous condition, prolonged use of trifluridine should be avoided.
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Authors | P C Maudgal, B Van Damme, L Missotten |
Journal | Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
(Graefes Arch Clin Exp Ophthalmol)
Vol. 220
Issue 1
Pg. 6-12
( 1983)
ISSN: 0721-832X [Print] Germany |
PMID | 6403411
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Antiviral Agents
- brivudine
- Bromodeoxyuridine
- Trifluridine
- Thymidine
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Topics |
- Age Factors
- Aged
- Antiviral Agents
(administration & dosage, adverse effects)
- Bromodeoxyuridine
(administration & dosage, analogs & derivatives)
- Cornea
(drug effects, pathology)
- Corneal Diseases
(chemically induced)
- Epithelium
(drug effects, pathology)
- Humans
- Keratitis, Dendritic
(drug therapy)
- Male
- Microscopy, Phase-Contrast
- Thymidine
(analogs & derivatives)
- Trifluridine
(administration & dosage, adverse effects, therapeutic use)
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