Treatment of Paget's disease of bone with ethane-1, hydroxy-1,1 diphosphonate (EHDP) at a low dosage (5 mg/kg/day).

Abstract

Paget's disease of bone in 51 patients was treated with ethane-1, hydroxy-1,1 diphosphonate (EHDP) for six months at a dosage of 5 mg/kg/day. Clinically, the analgesic effect on bone pain is clear, with parallel reduction in radioisotope uptake observed by quantitative bone scintigraphy. There is also a reduction of about 70% of the excess level of serum alkaline phosphatase and total 24-hour urinary hydroxyproline. Histologically, there is a significant reduction in both the osteoclastic resorption surfaces and the number of osteoclasts. In contrast to that obtained by calcitonin, these clinical, biologic, and histologic changes continue for at least one year beyond the end of the treatment. That is the main characteristic of this treatment, of which the clinical and biologic tolerance is admittedly very satisfactory. Accumulation of osteoid tissue, which is indicative of a mineralization defect, does not appear at low dosages under the prescribed conditions. EHDP (5 mg/kg/day) can be regarded as effective treatment for some patients with Paget's disease of bone.

• Authors: C M Alexandre, M C Chapuy, E Vignon, C Edouard, C C Johnston, P J Meunier
• Journal: Clinical orthopaedics and related research (Clin Orthop Relat Res) Issue 174 Pg. 193-205 (Apr 1983) ISSN: 0009-921X [Print] United States
• PMID: 6403270 (Publication Type: Journal Article)

Chemical References

• Alkaline Phosphatase
• Etidronic Acid
• Hydroxyproline

Topics

• Adult
• Aged
• Alkaline Phosphatase (blood)
• Blood Chemical Analysis
• Cell Count
• Drug Evaluation
• Etidronic Acid (administration & dosage)
• Female
• Humans
• Hydroxyproline (urine)
• Male
• Middle Aged
• Osteitis Deformans (diagnostic imaging, drug therapy, metabolism)
• Osteoclasts
• Pain (drug therapy)
• Radionuclide Imaging