Abstract |
The effects of octopamine on systemic and pulmonary circulation and on respiratory parameters have been studied in ten O2 100% breathing pigs. A rise in cardiac index (CI) due to an increase in the dynamics of the left ventricle and a progressive hypoxemia, notwithstanding the hyperventilation, was found. The decrease in arterial O2 tension was due to a rise in the pulmonary shunt fraction (QS/QT). The statistical analysis of cardiorespiratory parameters demonstrated that the high flow state linked with a non-Starling mechanism was the causing factor of a ventilation: perfusion ratio (VA/QT) decrease, which led to the rise in QS/QT. Also, a decrease in the lung compliance simultaneous to the increased blood flow was observed. It is suggested that octopamine may play a role in the pathogenesis of the cardiorespiratory hemodynamic impairment of cirrhosis and sepsis where high levels of this false neurotransmitter were observed.
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Authors | A Nespoli, O Chiara, M G Clement, G Dagnino, G Bevilacqua, G Aguggini |
Journal | Circulatory shock
(Circ Shock)
Vol. 10
Issue 1
Pg. 15-30
( 1983)
ISSN: 0092-6213 [Print] United States |
PMID | 6403256
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Animals
- Depression, Chemical
- Female
- Hemodynamics
(drug effects)
- Hypoxia
(chemically induced)
- Infusions, Parenteral
- Liver Cirrhosis
(physiopathology)
- Male
- Octopamine
(administration & dosage)
- Oxygen Consumption
(drug effects)
- Respiration
(drug effects)
- Shock, Septic
(physiopathology)
- Swine
- Ventilation-Perfusion Ratio
(drug effects)
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