Treatment of ragweed allergic conjunctivitis with cromolyn sodium 4% ophthalmic solution.

Abstract

We treated 31 patients with ragweed conjunctivitis in an eight-week, double-masked parallel-group study with cromolyn sodium 4% ophthalmic solution. Analysis of data showed preseason serum IgE antibody to ragweed level was a significant predictor of drug response. Of 16 patients with ragweed IgE values of less than 100 ng/ml, the nine treated with cromolyn had significantly fewer symptoms during the course of treatment than the seven in the placebo group. Of the 15 remaining patients, who had IgE levels of more than 100 ng/ml, the eight treated with cromolyn improved but the difference between their symptom scores and those of the seven patients treated with placebo was not statistically significant.

• Authors: G A Friday, A W Biglan, D A Hiles, S M Murphey, D L Miller, C Rothbach, S Rand
• Journal: American journal of ophthalmology (Am J Ophthalmol) Vol. 95 Issue 2 Pg. 169-74 (Feb 1983) ISSN: 0002-9394 [Print] United States
• PMID: 6401928 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies
• Immunoglobulin E
• Cromolyn Sodium

Topics

• Adolescent
• Adult
• Antibodies (analysis)
• Conjunctivitis (drug therapy, immunology)
• Cromolyn Sodium (therapeutic use)
• Double-Blind Method
• Female
• Humans
• Hypersensitivity (drug therapy)
• Immunoglobulin E (analysis)
• Male
• Middle Aged
• Pollen