Donor-to-host transmission of streptococcal infection by corneas stored in McCarey-Kaufman medium.

Abstract

Two patients developed streptococcal endophthalmitis following penetrating keratoplasty. These cases may represent the third and fourth cases of donor-to-host transmission of streptococcal infection by corneas stored in McCarey-Kaufman (M-K) medium. Streptococcal agents now account for 50-59% of the total number of reported cases of M-K medium contamination by donor tissue with resultant infection in the host. Gentamicin sulfate, the sole antibiotic used in the M-K medium in all cases, has poor activity against most streptococci. The addition of a second antibiotic to the M-K medium to provide an improved spectrum of antimicrobial activity should be considered.

• Authors: A Matoba, M B Moore, J L Merten, J P McCulley
• Journal: Cornea (Cornea) Vol. 3 Issue 2 Pg. 105-8 ( 1984) ISSN: 0277-3740 [Print] United States
• PMID: 6399232 (Publication Type: Case Reports, Journal Article)

Chemical References

• Gentamicins

Topics

• Aged
• Cornea (microbiology)
• Corneal Transplantation
• Endophthalmitis (microbiology, transmission)
• Female
• Gentamicins (pharmacology)
• Humans
• Streptococcal Infections (microbiology, transmission)
• Streptococcus (drug effects)
• Tissue Donors
• Tissue Preservation (methods)