Residual B-cell function in type 1 (insulin-dependent) diabetes mellitus: its relation to clinical and metabolic features.

Abstract

The aim of the present study was to investigate whether or not residual B-cell function could be related to insulin sensitivity as well as to duration of disease, insulin requirement, and indices of metabolic control in a population of Type 1 (insulin-dependent) diabetic patients. A positive correlation was found between fasting C-peptide and age at onset of diabetes, whereas a negative relationship occurred between C-peptide and duration of disease. Fasting C-peptide negatively correlated also to mean daily plasma glucose, 24-h glycosuria, and fasting free fatty acid concentration. Moreover, a negative correlation was found between C-peptide and daily insulin requirement. Conversely, a positive relationship occurred between C-peptide levels and the parameter we used for estimating insulin sensitivity, i.e. glucose disappearance rate after i.v. insulin injection. These results once more emphasize the importance of residual B-cell function in Type 1 (insulin-dependent) diabetes mellitus, and suggest that the residual endogenous insulin secretion might play an important role in glucose homeostasis of Type 1 diabetes by influencing the sensitivity to insulin.

• Authors: E Bonora, C Coscelli, U Butturini
• Journal: Acta diabetologica latina (Acta Diabetol Lat) 1984 Oct-Dec Vol. 21 Issue 4 Pg. 375-83 ISSN: 0001-5563 [Print] Italy
• PMID: 6397028 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Blood Glucose
• C-Peptide
• Fatty Acids, Nonesterified
• Insulin
• Glucose

Topics

• Adolescent
• Adult
• Blood Glucose (metabolism)
• C-Peptide (blood)
• Diabetes Mellitus, Type 1 (drug therapy, metabolism, physiopathology)
• Fasting
• Fatty Acids, Nonesterified (blood)
• Female
• Glucose (metabolism)
• Glycosuria (metabolism)
• Humans
• Insulin (administration & dosage, therapeutic use)
• Islets of Langerhans (physiopathology)
• Male
• Middle Aged