Controlled study of bromocriptine and placebo for induction of ovulation in normoprolactinemic secondary amenorrhea.

Abstract

In order to evaluate the effect of bromocriptine in the treatment of secondary amenorrhea, a double-blind placebo-controlled study including 30 women with normo-prolactinemic normo-hypogonadotropic hypogonadism was carried out. The patients were given either 5 mg bromocriptine or placebo every day for 12 weeks and observed during the following 3 months. A biphasic basal body temperature curve and serum progesterone levels exceeding 25 nmol/l during the expected midluteal phase were considered an indication of ovulation. Restoration of ovulation was observed in 2 of 17 women given bromocriptine and 4 of 13 women given placebo. Bromocriptine was found to have no specific effect on the restoration of ovulation in women with secondary amenorrhea and normoprolactinemic normo-hypogonadotropic hypogonadism.

• Authors: T Espersen, A C Thomsen
• Journal: Acta obstetricia et gynecologica Scandinavica (Acta Obstet Gynecol Scand) Vol. 63 Issue 8 Pg. 715-7 ( 1984) ISSN: 0001-6349 [Print] United States
• PMID: 6395615 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Bromocriptine
• Prolactin

Topics

• Adolescent
• Adult
• Amenorrhea (drug therapy)
• Bromocriptine (therapeutic use)
• Clinical Trials as Topic
• Double-Blind Method
• Female
• Humans
• Hypogonadism (drug therapy)
• Hypothalamus (physiopathology)
• Ovary (physiopathology)
• Ovulation Induction
• Prolactin (blood)