[Effect duration and dose-response relation of molsidomine in patients with coronary heart disease].

Abstract

The dose-effect relation and duration of action of 2 mg, 4 mg and 6 mg molsidomine on ischemic ST-segment depression in the exercise-ECG were determined in a randomized and double-blind acute study of 12 patients with confirmed coronary artery disease. With 2 mg molsidomine a significant reduction in the amount of ischemic ST-depression from 18.0 mm to 8.1 mm, 45% of the baseline-figure, resulted. With 6 mg molsidomine a diminuation of the ST-segment depression from 16.2 mm to 6 mm, approximately 40%, was noted. The significant antianginal effect of 2 mg molsidomine lasted at least 3 hours. After 5 hours an effect was seen only in some patients. 4 mg and 6 mg molsidomine still showed a significant reduction of ST-segment depression after 5 hours. A sufficient antianginal efect over 24 hours is only achieved with a 2-mg dose administered 5-6 times or with a 4-6 mg dose applied 4-5 times daily. The most marked fall in blood pressure was noticed after 6 mg molsidomine. On average, the systolic blood pressure fell 41 mm Hg (22%). Orthostatic reactions were not seen. The maximal dose-dependent plasma levels were 15.8 ng/ml, 30.1 ng/ml and 50.0 ng/ml. A definite, reliable clinical effect was seen in some cases from plasma levels above 2 ng/ml.

• Authors: W A Fach, H J Becker
• Journal: Zeitschrift fur Kardiologie (Z Kardiol) Vol. 73 Issue 10 Pg. 613-22 (Oct 1984) ISSN: 0300-5860 [Print] Germany
• Vernacular Title: Wirkdauer und Dosis-Wirkungs-Beziehung von Molsidomin bei Patienten mit koronarer Herzkrankheit.
• PMID: 6393621 (Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Oxadiazoles
• Sydnones
• Vasodilator Agents
• Molsidomine

Topics

• Angina Pectoris (drug therapy)
• Blood Pressure (drug effects)
• Clinical Trials as Topic
• Coronary Circulation (drug effects)
• Coronary Disease (drug therapy)
• Dose-Response Relationship, Drug
• Double-Blind Method
• Electrocardiography
• Exercise Test
• Heart Rate (drug effects)
• Humans
• Molsidomine
• Oxadiazoles (therapeutic use)
• Sydnones (blood, therapeutic use)
• Vasodilator Agents (therapeutic use)