Prevention of post-appendicectomy sepsis by mezlocillin and metronidazole: a prospective, randomized, double-blind trial.

Abstract	In a double-blind trial a 6% infection rate resulted from the use of a single peroperative dose of mezlocillin in emergency appendicectomy for non-perforated disease. No advantage was demonstrated by mezlocillin over the 8% infection rate achieved with metronidazole. There was only one anaerobic infection in the mezlocillin group although Bacteroides fragilis had been isolated at operation from all three infected cases and many other uninfected patients. No anaerobic infections were detected in the metronidazole group.
Authors	G S McIntosh, G Jacob, N H Townell, P Noone
Journal	The Journal of antimicrobial chemotherapy (J Antimicrob Chemother) Vol. 14 Issue 5 Pg. 537-42 (Nov 1984) ISSN: 0305-7453 [Print] England
PMID	6392282 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References	Metronidazole Mezlocillin
Topics	Adolescent Adult Appendectomy Child Child, Preschool Clinical Trials as Topic Double-Blind Method Female Humans Infant Male Metronidazole (therapeutic use) Mezlocillin (therapeutic use) Middle Aged Premedication Random Allocation Surgical Wound Infection (microbiology, prevention & control)

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