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Antitumor activity of amidoximes (hydroxyurea analogs) in murine tumor systems.

Abstract
A series of amidoximes was prepared and evaluated for possible antitumor activity against L1210 leukemia. Three of the most active compounds in the L1210 system, formamidoxime, acetamidoxime, and 2-aminoacetamidoxime hydrochloride, were also active against P388 leukemia. Acetamidoxime was marginally active against Lewis lung carcinoma. The active amidoximes showed best activity against L1210 leukemia when given two times daily, 5 hours apart, for 8 days. Most of the amidoximes produced excessive central nervous system stimulation.
AuthorsK P Flora, B van't Riet, G L Wampler
JournalCancer research (Cancer Res) Vol. 38 Issue 5 Pg. 1291-5 (May 1978) ISSN: 0008-5472 [Print] United States
PMID639062 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Amines
  • Antineoplastic Agents
  • Oximes
Topics
  • Amines (administration & dosage, pharmacology)
  • Animals
  • Antineoplastic Agents
  • Drug Evaluation, Preclinical
  • Female
  • Leukemia L1210 (drug therapy)
  • Leukemia, Experimental (drug therapy)
  • Lung Neoplasms (drug therapy)
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred DBA
  • Neoplasms, Experimental (drug therapy)
  • Oximes (administration & dosage, pharmacology)
  • Structure-Activity Relationship
  • Time Factors

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