Abstract |
A series of amidoximes was prepared and evaluated for possible antitumor activity against L1210 leukemia. Three of the most active compounds in the L1210 system, formamidoxime, acetamidoxime, and 2-aminoacetamidoxime hydrochloride, were also active against P388 leukemia. Acetamidoxime was marginally active against Lewis lung carcinoma. The active amidoximes showed best activity against L1210 leukemia when given two times daily, 5 hours apart, for 8 days. Most of the amidoximes produced excessive central nervous system stimulation.
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Authors | K P Flora, B van't Riet, G L Wampler |
Journal | Cancer research
(Cancer Res)
Vol. 38
Issue 5
Pg. 1291-5
(May 1978)
ISSN: 0008-5472 [Print] United States |
PMID | 639062
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Amines
- Antineoplastic Agents
- Oximes
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Topics |
- Amines
(administration & dosage, pharmacology)
- Animals
- Antineoplastic Agents
- Drug Evaluation, Preclinical
- Female
- Leukemia L1210
(drug therapy)
- Leukemia, Experimental
(drug therapy)
- Lung Neoplasms
(drug therapy)
- Mice
- Mice, Inbred C57BL
- Mice, Inbred DBA
- Neoplasms, Experimental
(drug therapy)
- Oximes
(administration & dosage, pharmacology)
- Structure-Activity Relationship
- Time Factors
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