HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Prolonged complete remission following high dose chemotherapy of Burkitt's lymphoma in relapse.

Abstract
Fourteen patients with American Burkitt's lymphoma resistant to conventional chemotherapy were treated with high-dose combination chemotherapy and intensive supportive care. Four patients died shortly after chemotherapy, 3 of an acute carditis. All ten remaining patients demonstrated tumor regression and 3 remain in prolonged complete unmaintained remission 29+, 19+, and 9+ months after treatment. These findings demonstrate that high-dose chemotherapy will benefit some patients with Burkitt's lymphoma unresponsive to conventional chemotherapy, but the medullary and extramedullary toxicity of this treatment strategy remains a formidable obstacle.
AuthorsF R Appelbaum, A B Deisseroth, R G Graw Jr, G P Herzig, A S Levine, I T Magrath, P A Pizzo, D G Poplack, J L Ziegler
JournalCancer (Cancer) Vol. 41 Issue 3 Pg. 1059-63 (Mar 1978) ISSN: 0008-543X [Print] United States
PMID638947 (Publication Type: Journal Article)
Chemical References
  • Cytarabine
  • Cyclophosphamide
  • Thioguanine
  • Carmustine
Topics
  • Adolescent
  • Adult
  • Burkitt Lymphoma (drug therapy)
  • Carmustine (administration & dosage, therapeutic use)
  • Child
  • Child, Preschool
  • Cyclophosphamide (administration & dosage, therapeutic use)
  • Cytarabine (administration & dosage, therapeutic use)
  • Drug Administration Schedule
  • Drug Therapy, Combination (adverse effects)
  • Female
  • Humans
  • Male
  • Myocarditis (chemically induced)
  • Remission, Spontaneous
  • Thioguanine (administration & dosage, therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: