Alclometasone dipropionate cream 0.05% versus clobetasone butyrate cream 0.05%. A controlled clinical comparison in the treatment of atopic dermatitis in children.

Abstract

A randomized, double-blind, parallel-group study was conducted comparing the efficacy and safety of alclometasone dipropionate cream 0.05% and clobetasone butyrate cream 0.05% in the treatment of atopic dermatitis in 43 children. The medications were applied to study areas as a thin layer of cream twice daily for 2 weeks. Efficacy was assessed by evaluation of three disease signs (erythema, induration, and pruritus) and by mean of a physician's global evaluation following treatment. Safety was evaluated through patient-reported and clinically observed adverse experiences. Both treatments were effective. At the end of the trial, average reduction in disease signs was 85% for alclometasone dipropionate-treated patients and 86% in the clobetasone butyrate-treated group. In the global evaluation, the physician rated symptoms as cleared in 9 of 22 alclometasone dipropionate-treated patients and in 10 of 21 clobetasone butyrate-treated patients.

• Authors: A Lassus
• Journal: International journal of dermatology (Int J Dermatol) Vol. 23 Issue 8 Pg. 565-6 (Oct 1984) ISSN: 0011-9059 [Print] England
• PMID: 6389385 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Inflammatory Agents
• clobetasone butyrate
• Betamethasone
• Clobetasol
• alclometasone dipropionate
• Methylprednisolone

Topics

• Administration, Topical
• Anti-Inflammatory Agents (administration & dosage, therapeutic use)
• Betamethasone (analogs & derivatives)
• Child
• Child, Preschool
• Clinical Trials as Topic
• Clobetasol (administration & dosage, analogs & derivatives, therapeutic use)
• Dermatitis, Atopic (drug therapy)
• Double-Blind Method
• Female
• Humans
• Male
• Methylprednisolone (administration & dosage, analogs & derivatives, therapeutic use)