Antibiotic prophylaxis for cardiovascular surgery. Efficacy with coronary artery bypass.

Abstract

Two hundred twenty patients were randomly assigned to receive either ceforanide or cephalothin as perioperative antibiotic prophylaxis during cardiovascular surgery. More infections were seen among cephalothin recipients (8 deep, 32 total) than among ceforanide recipients (1 deep, 17 total). Among patients who had only coronary artery bypass grafting, more cephalothin recipients had infection than did ceforanide recipients (19 of 82 as opposed to 7 of 83; p = 0.001; relative risk, 2.7; 95% confidence interval, 1.22 to 6.18). The difference between the two regimens was attributable to fewer blood, wound, and urinary tract infections. Among patients who had other procedures, there was no difference in the efficacy of the two regimens. Cephalothin recipients who developed wound or blood stream infections had lower antibiotic levels in their atrial appendages than recipients not developing such infections (p = 0.02). If one assumes that cephalothin does not increase the risk of infection, then these data show that antibiotic prophylaxis prevents infection after coronary artery bypass surgery, and, in the dosages used, that ceforanide is superior to cephalothin.

• Authors: R Platt, A Muñoz, J Stella, S VanDevanter, J K Koster Jr
• Journal: Annals of internal medicine (Ann Intern Med) Vol. 101 Issue 6 Pg. 770-4 (Dec 1984) ISSN: 0003-4819 [Print] United States
• PMID: 6388452 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Cefamandole
• ceforanide
• Cephalothin

Topics

• Cefamandole (analogs & derivatives, blood, metabolism, therapeutic use)
• Cephalothin (blood, metabolism, therapeutic use)
• Clinical Trials as Topic
• Coronary Artery Bypass
• Double-Blind Method
• Female
• Humans
• Male
• Microbial Sensitivity Tests
• Middle Aged
• Myocardium (metabolism)
• Postoperative Complications (prevention & control)
• Premedication
• Random Allocation
• Respiratory Tract Infections (prevention & control)
• Risk
• Sepsis (prevention & control)
• Surgical Wound Infection (prevention & control)
• Urinary Tract Infections (prevention & control)