Transient
renal glycosuria was observed in eight renal transplant patients during the recovery phase from initial tubular
necrosis or acute rejection. In these subjects and three homograft recipients without
glycosuria we performed
glucose titration experiments. Three patients were found to have type A
glycosuria, two had type B and three type C. The titration curve was normal in the three patients without
glycosuria. In addition, most subjects presented with hypophosphataemia and
hyperphosphaturia. Apart from a direct correlation between the point of splay of the
glucose titration curves and the fractional clearance of
phosphate, there was no clear-cut relationship between the handling of
glucose and
phosphorus. Mild hyperchloraemic
acidosis was observed in six subjects, but this was unrelated to the type and grade of
glycosuria. It is concluded that in homograft recipients the tubular alterations have a patchy and unpredictable distribution and may cause a variety of symptoms which do not necessarily occur in close association.