Evaluation of the 4-pyridinemethanol WR 180,409 (enpiroline) in the treatment of induced Plasmodium falciparum infections in healthy, non-immune subjects.

Abstract	WR 180,409 (enpiroline) was administered to 22 non-immune subjects infected with the multi-drug resistant Vietnam Smith isolate of Plasmodium falciparum. It was curative in single day treatment regimens with a minimum curative dose of approximately 10 mg/kg body weight. At this dose level it was well tolerated and produced rapid clearance of parasitemia in every case.
Authors	T M Cosgriff, E F Boudreau, C L Pamplin 3rd, J D Berman, M J Shmuklarsky, C J Canfield
Journal	The American journal of tropical medicine and hygiene (Am J Trop Med Hyg) Vol. 33 Issue 5 Pg. 767-71 (Sep 1984) ISSN: 0002-9637 [Print] United States
PMID	6385737 (Publication Type: Journal Article)
Chemical References	Pyridines enpiroline
Topics	Adolescent Adult Drug Evaluation Humans Malaria (drug therapy, parasitology) Plasmodium falciparum (drug effects) Pyridines (administration & dosage, adverse effects, therapeutic use)

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